neurology

A fully updated and authoritative neurology resource

The Queen Square Textbook has established itself as a favourite companion to clinical neurosciences training and teaching around the world, whilst retaining its role as an invaluable reference guide for physicians and other healthcare professionals working in neurology, general medicine and related specialties.

The book continues to reflect the core values essential to the practice of clinical neurology in the 21st century. The third edition has been extensively revised and updated to take account of the rapid pace of progress in the neurosciences and patient care. Contemporary neurology has been changed by the COVID-19 pandemic, the climate emergency and the growing inequalities in healthcare resources. The new edition has been extensively revised to reflect these challenges and affords a greater emphasis on management and rehabilitation whilst continuing to reflect the coherence of a text produced from a single, closely-knit, centre of excellence.

Highlights of the new edition include:

• An updated approach to clinical examination, decision-making and diagnosis
• New developments in neuroimmunology, pathology and genetics
• Neuropalliative care
• Ethical and legal issues in clinical neurology
• The latest developments in the understanding and management of stroke, movement disorders, epilepsy, cognitive impairment, multiple sclerosis, infections, myelopathy, anterior horn cell disease, disorders of nerve and muscle, neuro-oncology, neurological disorders of hearing, balance and vision, and the neurological care of critical illness, sleep, neuropsychiatry, pain, autonomic and urological disorders.
• An emphasis on treatment and rehabilitation of the person with a neurological disease

The new edition marks a significant transition to reflect contemporary neurological practice during uncertain times. It mirrors the enormous changes in investigation, diagnosis and treatment that have occurred in recent years whilst maintaining the underlying principle that we do not treat diagnoses but, rather, we care for people affected by neurological disease.

Contributors vii

About the Editors xiii

Foreword to the Third Edition xv

Preface to First Edition xvii

Preface to Second Edition xix

Preface to Third Edition xxi

Acknowledgements xxiii

1 Global Burden of Neurological Disease and the Neurology of Climate Change 1
Hadi Manji and Sanjay Sisodiya

2 Approach to the Patient with Neurological Disease 17
Robin Howard, Gerry Christofi, Alex Rossor, Jason Warren and David Werring

3 Decision Making, Ethics and Law in Neurology 37
Jonathan Martin and Alex Ruck Keene

4 Neuropathology: Introduction to History, Diagnostic Approaches, Techniques and their Interpretation 53
Sebastian Brandner

5 Neuroimaging 67
Frederik Barkhof and Francesco Carletti

6 Neurogenetics 79
Henry Houlden, Andrea Cortese and Edward J. Wild

7 Neuroimmunology 91
Michael Zandi, Aisling Carr, Rachel Brown and Michael Lunn

8 Stroke and Cerebrovascular Diseases 107
David Werring, Matthew Adams, Laura Benjamin, Martin Brown, Arvind Chandratheva, Peter Cowley, Joan Grieve, Fiona Humphries, Hans Rolf Jäger, Nicholas Losseff, Richard Perry, Robert Simister and Ahmed Toma

9 Movement Disorders 199
Thomas Foltynie, Kailash Bhatia, Carla Cordivari, Eileen Joyce, Prasad Korlipara, Patricia Limousin, Tabish A. Saifee, Sarah Tabrizi and Thomas Warner

10 Epilepsy and Related Disorders 247
John Duncan, Josemir Sander, Ali Alim-Marvasti, Simona Balestrini, Sallie Baxendale, Dorothea Bindman, Krishna Chinthapalli, Fahmida Chowdhury, Beate Diehl, Sofia Eriksson, Jackie Foong, Dominic Heaney, Sofia Khan, Matthias Koepp, Dimitri Kullmann, Sanjeev Rajakulendran, Fergus Rugg-Gunn, Meneka Sidhu, Sanjay Sisodiya, Jane de Tisi, Maria Thom, Matthew Walker and Mahinda Yogarajah

11 Cognitive Impairment and Dementia 319
Jason Warren, John Collinge, Nick Fox, Simon Mead, Catherine Mummery, Jonathan Rohrer, Martin Rossor, Jonathan Schott and Rimona Weil

12 Infection in the Nervous System 369
Robin Howard, Laura Benjamin, Sophia De-Saram, Catherine Houlihan and Hadi Manji

13 Cranial Nerve Disorders 433
Robin Howard, Jeremy Chataway and Paul Jarman

14 Spinal Column and Spinal Cord Disorders 463
Tabish A. Saifee, Simon Farmer, Sachit Shah and David Choi

15 Disorders of the Motor Cells: The Motor Neuron Diseases 499
Andrea Malaspina, Jan Clarke, Pietro Fratta, Robin Howard, Ross Nortley, Richard Orrell, Rickie Patani, Katie Sidle and Michaela Waltho

16 Diseases of the Peripheral Nerves 517
Michael Lunn, Alex Rossor and Mary Reilly

17 Disorders of the Neuromuscular Junction 561
Jennifer Spillane, Robin Howard, Dimitri Kullmann and Georgiana Logou

18 Disorders of Muscle 575
Jasper Morrow, Michael Hanna, Matt Parton and Christopher Turner

19 Multiple Sclerosis and Demyelinating Diseases 603
Siobhan Leary, Wallace Brownlee, Noreen Barker, Declan Chard, Jeremy Chataway, Karen Chung, Olga Ciccarelli, Gavin Giovannoni, Nevin John, Zhaleh Khaleeli, Josephine Swanton, Ahmed Toosy, Anand Trip, Heather Wilson and Alan Thompson

20 Neuro-Oncology 655
Jeremy Rees, Sebastian Brandner, Naomi Fersht, Joan Grieve, Gary Hotton, Michael Kosmin, Vittorio Russo, Lewis Thorne and Steffi Thust

21 Headache 721
Manjit Matharu, Paul Shanahan, Tim Young and Salwa Kamourieh

22 Neuro-Ophthalmology 741
James Acheson, Fion Bremner, Sara Ajina, Gordon Plant, Robin Howard, Alexander Leff and Ahmed Toosy

23 Neuro-Otology: Dizziness, Balance and Hearing 797
Diego Kaski, Doris-Eva Bamiou, Adolfo Bronstein and Nehzat Koohi

24 Cerebellar Ataxias and Related Conditions 839
Nicholas Wood

25 Restorative Neurology, Rehabilitation and Brain Injury 855
Valerie Stevenson, Sara Ajina, Gerry Christofi, Rachel Farrell, Richard Greenwood, Camille Julien, Siobhan Leary, Alexander Leff, Orlando Swayne, Richard Sylvester and Nick Ward

26 Toxic, Metabolic and Physical Insults to the Nervous System 903
Robin Howard, Talal Al-Mayhani, Aisling Carr, Alexander Leff, Jasper Morrow and Alexander Rossor

27 Inherited Disorders of Metabolism 945
Elaine Murphy, Charlotte Ellerton, Simon Heales, Robin Lachmann, David Lynch and Robert Pitceathly

28 Disorders of Consciousness and Intensive Care Neurology 987
Robin Howard, Dimitri Kullmann, Andrew Paget, Jennifer Spillane and Manni Waraich

29 Disorders of Sleep 1049
Sofia Eriksson, Robin Howard, Sofia Khan and Matthew Walker

30 Neuropsychiatry 1061
Eileen Joyce and Dorothea Bindman

31 Pain in Neurological Disorders 1075
Alan Fayaz and Anupam Bhattacharjee

32 Autonomic Aspects of Neurology 1097
Valeria Iodice, Gordon Ingle, Christopher Mathias and Patricia McNamara

33 Uro-Neurology 1137
Jalesh N. Panicker, Sara Simeoni and Mahreen Pakzad

34 Systemic Conditions and Neurology 1155
David Werring, Aisling Carr, Robin Howard, Dimitri Kullmann and Michael Zandi

35 Palliative Care in Neurology 1203
Jonathan Martin, Jan Clarke, Robin Howard and Michaela Waltho

Index 1219

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