In this issue of Psychiatric Clinics, guest editors Drs. Manish K. Jha and Madhukar H. Trivedi bring their considerable expertise to the topic of Treatment-Resistant Depression. Treatment-resistant depression (TRD), when patients experience an inadequate response to standard treatment plans, is a relatively common occurrence in clinical practice. In this issue, top experts shed light on this difficult-to-treat disorder, helping healthcare professionals improve outcomes for their patients with TRD.

• Contains 15 practice-oriented topics including overview of TRD; improving depression outcomes through measurement-based care; approach to diagnosis and treatment for difficult-to-treat depression; TRD in children and in the elderly; neuroimaging biomarkers of treatment-resistant depression; the role of psychedelics in TRD; and more. 

• Provides in-depth clinical reviews on treatment-resistant depression, offering actionable insights for clinical practice. 

• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 

The Individual and Societal Burden of Treatment-Resistant Depression: An Overview

Improving Identification and Treatment Outcomes of Treatment-Resistant Depression Through Measurement-Based Care

Approach to Diagnosis and Management of Treatment-Resistant Depression

Pharmacotherapy for Treatment-Resistant Depression: Antidepressants and Atypical Antipsychotics

Pharmacotherapy: Ketamine and Esketamine

Role of Psychedelics in Treatment-Resistant Depression

Noninvasive Brain Stimulation Techniques for Treatment-Resistant Depression: Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation

Photobiomodulation: An Emerging Treatment Modality for Depression

The Role of Psychotherapy in the Management of Treatment-Resistant Depression

Special Populations: Treatment-Resistant Depression in Children and Adolescents

Treatment-Resistant Late-Life Depression: A Review of Clinical Features, Neuropsychology, Neurobiology, and Treatment

Brain Features of Treatment-Resistant Depression: A Review of Structural and Functional Connectivity Magnetic Resonance Imaging Studies

Immune Dysregulation in Treatment-Resistant Depression: Precision Approaches to Treatment Selection and Development of Novel Treatments

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