In this issue of Sleep Medicine Clinics, guest editor Dr. Krishna M. Sundar brings his considerable expertise to the topic of Overlap of Respiratory Problems with Sleep Disordered Breathing. Given the rising prevalence of obesity and increasing demand for chronic respiratory support in pulmonary and chest wall disorders, this issue offers articles from top experts on seamlessly integrating the management of sleep-disordered breathing with novel ventilatory strategies employed for chronic respiratory failure.

• Contains 15 relevant, practice-oriented topics including mechanical interactions between upper airway and lower airways that affect propensity to sleep-disordered breathing; effects of sleep apnea on airway immunity and susceptibility to infection; epigenetic alterations, oxidative stress and telomere shortening from OSA: implications for chronic lung disease; obstructive sleep apnea and chronic cough; and more.
• Provides in-depth clinical reviews on overlap of respiratory problems with sleep disordered breathing, offering actionable insights for clinical practice.
• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Mechanical Interactions Between the Upper Airway and the Lungs that Affect the Propensity to Obstructive Sleep Apnea in Health and Chronic Lung Disease
Effects of Obstructive Sleep Apnea on Airway Immunity and Susceptibility to Respiratory Infections
Hypoxic and Autonomic Mechanisms from Sleep-Disordered Breathing Leading to Cardiopulmonary Dysfunction
Chronic Cough and Obstructive Sleep Apnea
Does Obstructive Sleep Apnea Lead to Progression of Chronic Obstructive Pulmonary Disease
Contribution of Obstructive Sleep Apnea to Asthmatic Airway Inflammation and Impact of Its Treatment on the Course of Asthma
Obstructive Sleep Apnea Effects on Chronic Airway Disease Exacerbations—Missed Opportunities for Improving Outcomes in Chronic Obstructive Pulmonary Disease and Asthma
Untreated Obstructive Sleep Apnea in Interstitial Lung Disease and Impact on Interstitial Lung Disease Outcomes
Obstructive Sleep Apnea and Sarcoidosis Interactions
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome, and Pulmonary Hypertension: A State-of-the-Art Review
Intermittent Versus Sustained Hypoxemia from Sleep-disordered Breathing: Outcomes in Patients with Chronic Lung Disease and High Altitude
The Role of Obstructive Sleep Apnea in Hypercapnic Respiratory Failure Identified in Critical Care, Inpatient, and Outpatient Settings
Targeting Hypercapnia in Chronic Lung Disease and Obesity Hypoventilation: Benefits and Challenges
Dyspnea and Quality of Life Improvements with Management of Comorbid Obstructive Sleep Apnea in Chronic Lung Disease

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