Hugo & Russell’s Pharmaceutical Microbiology

Discover the very latest developments in pharmaceutical microbiology in the 9th edition of this popular textbook

Microbiology is one of the essential pharmaceutical sciences upon which the study and practice of pharmacy is built. It has a bearing on all aspects of the manufacture of medicines and sterile products, from their design and development to their delivery as quality products. Few interventions are more central to modern medicine than the treatment of infection, where antibiosis, vaccination and hygienic practices have essential roles to play. The COVID-19 pandemic, the appearance of new pathogens and the rise of antibiotic resistance have demonstrated most completely the need for pharmaceutical practitioners, researchers and industrial scientists to be fully conversant with this field.

The 9th edition of Hugo and Russell’s Pharmaceutical Microbiology has been updated to meet this need. Having long served as the sole comprehensive textbook covering this subject, it has now been adapted to a critical new period in the advancement of medical and pharmaceutical research and development. Its experienced editors have incorporated contributions from subject experts and created a text which will serve the next generation of pharmacy students, pharmaceutical industry scientists and researchers.

In this ninth edition of Hugo and Russell’s Pharmaceutical Microbiology, readers will find:

• A mix of established and new authors bringing practical and research experience to their chapters
• Material covering the fundamentals of microbiology, microbial behavior and laboratory investigation
• Revised chapters incorporating new material on microbe-host interactions, antibiotic resistance, emerging pathogens, public health microbiology, healthcare-associated infection and pharmaceutical manufacture
• Emerging understandings from the COVID-19 pandemic on infection prevention and control and vaccine development
• Practitioners providing their insights on clinical practice and pharmaceutical production
• An accompanying website incorporating teaching resources

Hugo and Russell’s Pharmaceutical Microbiology, 9th edition promises to remain the essential text for pharmacy and medical students, as well as researchers and industry professionals.

Notes on Contributors vii

Preface to the First Edition ix

Preface to the Ninth Edition x

About the Companion Website xi

Part 1 Introducing Pharmaceutical Microbiology 1

1 Introduction to Pharmaceutical Microbiology 3
Brendan F. Gilmore and Stephen P. Denyer

Part 2 Biology of Microorganisms 11

2 Fundamental Features of Microbiology 13
Norman Hodges and Stephen P. Denyer

3 Bacteria 27
David Allison

4 Fungi 47
Kevin Kavanagh

5 Viruses and Other Acellular Infectious Agents: Characteristics and Control 63
Timofey Skvortsov and Jean-Yves Maillard

6 Protozoa 98
Tim Paget

Part 3 Pathogens and Host Response 121

7 Principles of Microbial Pathogenicity and Epidemiology 123
David Allison and Andrew J. McBain

8 Microbial Biofilms: Consequences for Health 135
Brendan F. Gilmore

9 Immunology 147
Mark Gumbleton and Mathew W. Smith

10 Vaccination and Immunisation 174
Gavin J. Humphreys and Andrew J. McBain

Part 4 Prescribing Therapeutics and Infection Control 191

11 Antibiotics and Synthetic Antimicrobial Agents: Their Properties and Uses 193
Brendan F. Gilmore

12 Mechanisms of Action of Antibiotics and Synthetic Anti-infective Agents 232
Peter Lambert

13 Bacterial Resistance to Antibiotics 249
Brendan F. Gilmore and Stephen P. Denyer

14 Clinical Uses of Antimicrobial Drugs 272
Hayley Wickens and Conor Jamieson

15 Antibiotic Prescribing and Antimicrobial Stewardship 289
Rebecca Craig

16 Infection Prevention and Control: Healthcare-associated Infection 304
Elaine Cloutman-Green

Part 5 Contamination and Contamination Control 321

17 Microbial Spoilage, Infection Risk and Contamination Control 323
Rosamund M. Baird

18 Chemical Disinfectants,Antiseptics and Preservatives 343
Sean P. Gorman and Brendan F. Gilmore

19 Laboratory Evaluation of Antimicrobial Agents 365
Brendan F. Gilmore and Sean P. Gorman

20 Microbicides: Mode of Action and Resistance 385
Stephen P. Denyer and Jean-Yves Maillard

21 Sterilisation Procedures and Sterility Assurance 403
Alistair K. Brown and Stephen P. Denyer

Part 6 Pharmaceutical Production 433

22 Sterile Pharmaceutical Products and Principles of Good Manufacturing Practice 435
Tim Sandle

23 The Manufacture and Quality Control of Immunological Products 462
Tim Sandle

24 Recombinant DNA Technology 480
Miguel Cámara and Stephan Heeb

Part 7 Current Trends and New Directions 507

25 The Wider Contribution of Microbiology to the Pharmaceutical Sciences 509
Mathew W. Smith, James C. Birchall and Sion A. Coulman

26 Alternative Strategies to Antibiotics: Priorities for Development 529
Brendan F. Gilmore

Index 544

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