CORONAVIRUS DISEASE 2019 (COVID-19)

Provides comprehensive coverage of all key aspects of COVID-19, including: etiology, diagnosis, symptomatology, management, and treatment

Coronavirus Disease 2019 (COVID-19): A Clinical Guide provides healthcare professionals at all levels with up-to-date knowledge about the clinical, epidemiological, genomic, virological, and radiologic features of COVID-19. Consolidating multiple systematic reviews and meta-analyses into a single volume, this comprehensive textbook also addresses health policies, mass casualty planning, healthcare worker safety, economic impact, lessons for future outbreaks, and other para-clinical and social aspects of the COVID-19 pandemic.

The text presents a thorough summary and critical analysis of COVID-19 based on an exhaustive review of recently published literature and data. Topics include the virologic characteristics of SARS-CoV-2, pulmonary and extrapulmonary manifestations and consequences of COVID-19, prevention and transmission control, the pandemic’s indirect impact to the care and management of other diseases, passive immunotherapy and its implications, diagnostic and treatment approaches for critically ill patients, and more. Edited by leading ­practitioners at the forefront of COVID-19 research, this invaluable resource:

• Integrates clinical, radiological, and epidemiological data and discussion of prevention, diagnosis, and treatment
• Reviews the epidemiology, mechanisms of action, manifestations, and management of cardiovascular, neurological, and pulmonary diseases associated with COVID-19
• Covers diagnostic technologies, includes radiologic imaging, and RT-PCR testing
• Explores therapeutic approaches for managing a variety of complications
• Discusses post-vaccination symptom management and implications of immunization
• Addresses COVID-19 in pediatrics, in cancer patients, and in patients with lung disease, diabetes, ­hypertension, obesity, and other underlying conditions

Coronavirus Disease 2019 (COVID-19): A Clinical Guide is an indispensable source of information for all clinicians, researchers, epidemiologists, nurses, radiologists, and healthcare managers working to address any aspect of the COVID-19 pandemic.

List of Contributors x

Preface xvii

1 COVID-19: Epidemiology 1
Phillip Quiroz, George W. Rutherford, and Michael P. Dube

2 COVID-19: Virology 22
Saeideh Najafi, Salar Tofighi, and Juliana Sobczyk

3 COVID-19: Laboratory/Serologic Diagnostics 34
Desmond Chin, Liesl S. Eibschutz, Juliana Sobczyk, Mobin Azami, Michael Jovan Repajic, and Michael P. Dube

4 COVID-19: Radiologic Diagnosis 61
Brian P. Pogatchnik, Wakana Murakami, and Shabnam Mortazavi

5 COVID-19: Pathology Perspective 101
Elham Hatami, Hana Russo, and Grace Y. Lin

6 COVID-19: Immunology 112
Yasaswi V. Vengalasetti, Niyousha Naderi, Christian Vega, Akhilesh Kumar, and Andrew T. Catanzaro

7 COVID-19: Presentation and Symptomatology 125
Jacek Czubak, Karolina Stolarczyk, Marcin Fraczek, Katarzyna Resler, Anna Orzel, Wojciech Flieger, and Tomasz Zatonìski

8 COVID-19: Risk Stratification 149
Dominique Duncan, Rachael Garner, and Yujia Zhang

9 COVID-19: Outpatient Management in Adults 165
Michael P. Dubé

10 COVID-19: Inpatient Management 182
Angelena Lopez, Yuri Matusov, Isabel Pedraza, Victor Tapson, Jeremy Falk, and Peter Chen

11 COVID-19: ICU and Critical Care Management 233
Daniel Crouch, Alexandra Rose, Cameron McGuire, Jenny Yang, Mazen Odish, and Amy Bellinghausen

12 COVID-19 in Pediatrics 255
Erlinda R. Ulloa, Kaidi He, Erin Chung, Delma Nieves, David E. Michalik, and Behnoosh Afghani

13 Pharmacologic Therapeutics for COVID-19 290
Amanda M. Burkhardt, Angela Lu, Isaac Asante, and Stan Louie

14 Co-infections and Secondary Infections in COVID-19 Pneumonia 319
Sanaz Katal, Liesl S. Eibschutz, Amit Gupta, Sean K. Johnston, Lucia Flors, and Ali Gholamrezanezhad

15 COVID-19: Neurology Perspective 339
Kiandokht Keyhanian, Raffaella Pizzolato Umeton, Babak Mohit, Brooke McNeilly, and Mehdi Ghasemi

16 COVID-19: Cardiology Perspective 361
Michael DiVita, Meshe Chonde, Megan Kamath, Darko Vucicevic, Ashley M. Fan, Arnold S. Baas, and Jeffrey J. Hsu

17 COVID-19: Oncologic and Hematologic Considerations 389
Diana L. Hanna, Caroline I. Piatek, Binh T. Ngo, and Heinz-Josef Lenz

18 COVID-19: Dermatology Perspective 409
Sabha Mushtaq, Fabrizio Fantini, and Sebastiano Recalcati

19 COVID-19: Ophthalmology Perspective 417
Hashem Al-Marzouki, Benjamin P. Hammond, Wendy W. Huang, and Angela N. Buffenn

20 COVID-19: Nutrition Perspectives 428
Emma J. Ridley, Lee-anne S. Chapple, Aidan Burrell, Kate Fetterplace, Amy Freeman-Sanderson, Andrea P. Marshall, and Ary Serpa Neto

21 COVID-19: Nursing Perspective 454
Michelle Zappas, Dalia Copti, Cynthia Sanchez, Janett A. Hildebrand, and Sharon O`Neill

22 COVID-19 Vaccination 472
Anurag Singh, Simran P. Kaur, Mohd Fardeen Husain Shahanshah, Bhawna Sharma, Vijay K. Chaudhary, Sanjay Gupta, and Vandana Gupta

23 Post-COVID-19 Vaccine Imaging Findings 494
Shadi Asadollahi, Liesl S. Eibschutz, Sanaz Katal, Vorada Sakulsaengprapha, Yasaswi Vengalasetti, Nikoo Saeedi, Sean K. Johnston, and Jennifer H. Johnston

24 COVID-19: Long-Term Pulmonary Consequences 515
Liesl S. Eibschutz, Tianyuan Fu, Boniface Yarabe, Narges Jokar, Sanaz Katal, Charlotte Sackett, Michael Repajic, and Ching-Fei Chang

25 Psychological Effects and Neuropsychiatric Sequelae in COVID-19 Patients 539
Elpitha Sakka, Arturas Kalniunas, Elzbieta Vitkauskaite, Wala Salman, Subhana Chaudhri, and Sofia Pappa

26 Mental Health Effects of the COVID-19 Pandemic on Healthcare Professionals 554
Liesl S. Eibschutz, Charlotte Sackett, Vorada Sakulsaengprapha, Masoomeh Faghankhani, Glenn Baumann, and Sofia Pappa

27 COVID-19: Ethical Considerations in Clinical Practice 580
Kiarash Aramesh

28 Racial, Ethnic, and Other Disparities in the Epidemiology and Care of COVID-19 586
Liesl S. Eibschutz, Charlotte Sackett, Kalpana Dave, Sarah Cherukury, Christian Vega, Mauricio Bueno, and Hector Flores

29 Global Impact of COVID-19 on Healthcare Systems 615
Liesl S. Eibschutz, Alexander A. Bruckhaus, Alexis Bennett, Dominique Duncan, Charlotte Sackett, Kalpana Dave, Sarah Cherukury, Victoria Uram, and Calvin M. Smith

30 COVID-19: Mass Casualty Planning 651
Lee Myers

Index 658

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