There are a number of diseases, such as ascites, renal dysfunction, cirrhosis and hypertension where both the liver and the kidney are involved. In addition, both organs are very important in regulating extracellular fluid volume, and how they work together or don’t work together can affect circulation and the heart. There has been very little written in the literature on the interaction of the two organs. This book addresses that problem.
The first edition of Ascites and Renal Dysfunction in Liver Disease was published in January 1999 and received extremely positive reviews:

‘There is no doubt that this textbook is essential, even for confirmed practitioners’ Acta Gastro-enterologica Belgica

‘Current information regarding treatment and therapy for patients with cirrhosis and ascites is clearly and effectively presented by the top international experts within this field’ Scandinavian Journal of Gastroenterology

The second edition is entirely revised and updated and the contents place greater emphasis on therapy.

Part 1 Regulation of Extracellular Fluid Volume and Renal and Splanchnic Circulation 1 Extracellualr fluid volume homeostasis 2 Physiology of the renal circulation 3 Physiology of the gastrointestinal circulation Part 2 Factors Involved in the Pathogenesis of Renal Dysfunction and Ascites in Cirrhosis 4 The renin-angiotensin-Aldosterone system in cirrhosis 5 The sympathetic nervous system in cirrhosis 6 Atrial natriuretic peptide and other natriuretic factors in cirrhosis 7 Arachidonic acid metabolites and the kidney in cirrhosis 8 Nitric oxide and systemic and renal hemodynamic disturbances in cirrhosis 9 Endothelin and systemic, renal and hepatic hemodynamic disturbances in Cirrhosis 10 Carbon monoxide and the hemeoxygenase system in cirrhosis Part 3 Systemic and Splanchnic Hemo-dynamic Abnormalities in Cirrhosis 11 The systemic circulation in cirrhosis 12 The splanchnic circulation in cirrhosis 13 Physiology of hepatic circulation in cirrhosis 14 Alterations of hepatic and splanchnic microvascular exchange in cirrhosis: local factors in the formation of ascites 15 The heart in cirrhosis Part 4 Ascites and sodium retention in cirrhosis 16 Pathogenesis of sodium retention in cirrhosis. The arterial vasodilation hypotheses of ascites formation 17 Experimental Models of Cirrhosis and Ascites 18 Medical treatment of ascites in cirrhosis 19 Paracentesis for cirrhotic ascites 20 Transjugular intrahepatic portosystemic shunts - TIPS for the management of refractory ascites in cirrhosis 21 Prognosis of patients with cirrhosis and ascites 22 Liver transplantation for patients with cirrhosis 23 A Practical approach to treatment of patients with cirrhosis and ascites 24 Etiology, diagnosis, and managment of non-cirrhotic ascites Part 5 Hyponatremia and water retention in cirrhosis 25 Pathogenesis of hyponatremia. The role of argenine vasopressin 26 Management of hyponatremia in cirrhosis Part 6 Spontaneous bacterial peritonitis in cirrhosis 27 Pathogenesis of renal vasoconstriction in cirrhosis 28 Hepatorenal syndrome in cirrhosis: Clinical, diagnosis, and management 29 Glomerular disease in cirrhosis 30 Drug-induced renal failure in cirrhosis 31 Clinical disorders of renal function in acute liver failure 32 Renal dysfunction in obstructive jaundice Part 7 Spontaneous bacterial peritonitis in cirrhosis 33 Experimental models of spontaneous bacterial peritonitis 34 Pathogenesis and clinical features of spontaneous bacterial peritonitis 35 Treatment and prohylaxis of spontaneous bacterial peritonitis

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